- Causes Colon Cancer
- Genetical Mutations of Genes, Which Raise the Colon Cancer
- Relationship of Dietary Regimen and Colon Cancer
- Risk Factor
Causes Colon Cancer
Generally, the causative agent of colon cancer is not at all evident. There is a professional point of view, that colon cancer happens when healthy cells reveal errors in their DNA.
In a healthy state, the process of cells` growth and development is carried systematically in order to keep one`s body normal functioning. As soon as cells` DNA is impacted and grows malignant, such cells go on dividing, though new cells are not required. The accumulation of cells leads to tumors.
Eventually, oncogenous cells start to intrude and damage close healthy tissue. Moreover, oncogenous cells can migrate to other body regions.
Genetical Mutations of Genes, Which Raise the Colon Cancer
Genetical mutations of genes, which raise the colon cancer likelihood of occurrence happen in families. However, this cause is related to the insignificant quantity of colon cancer cases. These kinds of gene mutations do not ensure colon cancer, but they include such individuals into the risk group
There are the most widespread types of genetical colon cancer syndromes:
- HNPCC, which is also called Lynch syndrome, raise the colon cancer and other kinds of cancer likelihood of occurrence. Moreover, patients having HNPCC, have a risk to get colon cancer before fifty years of age.
- Gardner`s syndrome or FAP (Familial adenomatous polyposis) sometimes results in many polyps inside one`s colon or rectum. Though this disease is a rare case, being untreated, it can lead to colon cancer progression at the age under forty.
HNPCC, FAP and some other genetic disorders leading to colon cancer can be revealed with the help of genetic analysis. In case one is worried of the familial colon cancer history, one should discuss with the doctor any possible risk of colon cancer development.
Relationship of Dietary Regimen and Colon Cancer
Check studies of big groups of patients reveal a close relationship of a habitual Western dietary regimen and colon cancer likelihood. It happens, because this type of diet is rather fattening and contains less fibers.
As soon as people change their region with habitual dietary regimen containing more fibers than fat for a region with a traditional Western food reach in fat, the likelihood of colon cancer redoubles. There is no scientific explanation to this fact. However, specialists involved in studies try to find out if a dietary regimen reach in fat and having lack of fibers impacts microorganisms living inside the colon or produce inflammatory process, which can lead to cancer onset. This is the sphere of follow-up studies.
There are the following pathology risk factors, which increase colon cancer likelihood:
- Elderly age: the majority of colon cancer cases happen after 50 years of age. Of course, there are cases at a young age, but it happens less often.
- Afro-American origin. People of this race have a higher probability to develop colon cancer.
- Personal cases of colorectal cancer or polyps in the past, which raise the colon cancer likelihood of occurrence in the future.
- Inflammation in digestive tract. Some diseases of digestive tract (as ulcerative colitis and Crohn’s disease) can lead to colon cancer onset.
- Familial symptoms, which raise the colon cancer likelihood. They include inherited adenomatous polyposis and hereditary nonpolyposis colorectal cancer, which is also known as Lynch syndrome.
- Cases of colon cancer in one`s family. It means, the presence of more than one family members affected with colon or rectal cancer can raise the risk of colon cancer development.
- Dietary regimen reach in fat and poor in fibers. Colon cancer onset can be connected with one`s diet. There are results of scientific studies, which show that people, who eat more red and processed meat, have a higher risk of colon cancer.
- Inactive lifestyle. Thus, health enhancing physical activity can reduce one`s risk of colon cancer.
- Diabetes. Different types of diabetes can provoke colon cancer.
- Corpulence. Corpulent people have a higher risk of colon cancer. Moreover, mortality from this disease among corpulent people is higher compared with people having normal weight.
- Smoking increases colon cancer risk.
- Abusive drinking behavior can increase one`s risk of colon cancer.
- Radiological therapy for cancer. This type of treatment directed at the abdomen in case of previous cancers can lead to colon cancer in one`s future.